Thursday, January 10, 2013

More Options to Dock Your iPhone 5 From Philips - NYTimes.com

Hoping to satisfy iPhone 5 users, the Dutch electronics maker Philips has introduced an array of docking speakers with Apple Lightning connectors.

Two of the more basic units are simply revamped models from the company?s existing lineup. If you already have either of these products with the older 30-pin connector, you won?t see anything new here.

The smaller of the two, the $90 Bedroom Docking Speaker, has a digital clock that automatically synchronizes the time with your iPhone and an adjustable nightlight underneath that emits a soft glow. It does not have an alarm mode, but that would be redundant because I have all of my alarms set in my iPhone anyway.

The sleek, round design of the docking speaker offers 360 degrees of sound, which was enough to fill my tiny bedroom. A protruding Lightning connector at the top of the device is intended to allow docking even when the iPhone is in its case, as I was able to do with mine.

The second model, the $129 Room to Room Docking Speaker, does not have a clock, but offers better sound from its front-facing speakers, with a bass that is noticeably deeper and richer. It also allows for docking without removing the iPhone?s case.

Which one you pick depends on your needs. Philips has two other docking speakers that offer more features, like portability and an FM radio. Personally, I liked the bedroom dock because of its size and practicality; it fits perfectly on a bedside table.

I have yet to find one on store shelves, but the new models are expected to show up at Best Buy first, then Target and Amazon.com, offering consumers a few more options for cradling their iPhones.

Source: http://gadgetwise.blogs.nytimes.com/2013/01/09/more-options-to-dock-your-iphone-5-from-philips/

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Wednesday, January 9, 2013

Biden to meet with gun-safety groups

WASHINGTON (AP) ? Seeking to spur fresh action on gun legislation, Vice President Joe Biden is meeting at the White House with victims groups and gun-safety organizations.

Wednesday's meeting is to be part of a series of gatherings Biden is conducting this week at the White House, aimed at building consensus around proposals to curb gun violence following the horrific elementary school shooting in Newtown, Conn. The vice president will meet Thursday with the National Rifle Association and other gun-owner groups. Meetings with representatives from the video-game and entertainment industries are also planned.

President Barack Obama wants Biden to report back to him with policy proposals by the end of the month. Obama has vowed to move swiftly on the recommendations, a package expected to include both legislative proposals and executive action.

"He is mindful of the need to act," White House spokesman Jay Carney said Tuesday.

But as the shock and sorrow over the Newtown, Conn., shooting fade, the tough fight facing the White House and gun-control backers is growing clearer. Gun-rights advocates, including the powerful NRA, are digging in against tighter gun restrictions, conservative groups are launching pro-gun initiatives, and the Senate's top Republican has warned it could be spring before Congress begins considering any gun legislation.

"The biggest problem we have at the moment is spending and debt," Senate Minority Leader Mitch McConnell of Kentucky, said Sunday. "That's going to dominate the Congress between now and the end of March. None of these issues will have the kind of priority as spending and debt over the next two or three months."

The killing of 6- and 7-year-olds at Newtown's Sandy Hook Elementary School on Dec. 14 appeared to stir a deep reaction from the White House and Capitol Hill. Obama pushed gun control to the top of his domestic agenda for the first time and pledged to put the full weight of his presidency behind the issue. And some Republican and conservative lawmakers with strong gun-rights records also took the extraordinary step of calling for a discussion on new measures.

But other gun-rights advocates have shown less flexibility. The NRA has rejected stricter gun legislation and suggested instead that the government put armed guards in every school in America as a way to curb violence. A coalition of conservative groups is also organizing a "Gun Appreciation Day" later this month, to coincide with Obama's inauguration.

The president hopes to announce his administration's next steps to tackle gun violence shortly after he is sworn in for a second term on Jan. 21.

Obama wants Congress to reinstate a ban on military-style assault weapons, close loopholes that allow gun buyers to skirt background checks and restrict high-capacity magazines. Other recommendations to the Biden group include making gun-trafficking a felony, getting the Justice Department to prosecute people caught lying on gun background-check forms and ordering federal agencies to send data to the National Gun Background Check Database.

Some of those steps could be taken through executive action, without the approval of Congress. White House officials say Obama will not finalize any actions until receiving Biden's recommendations.

Gun-rights lawmakers and outside groups have insisted that any policy response to the Newtown shooting also include an examination of mental health policies and the impact of violent movies and video games. To those people, the White House has pledged a comprehensive response.

"It is not a problem that can be solved by any specific action or single action that the government might take," Carney said. "It's a problem that encompasses issues of mental health, of education, as well as access to guns."

In addition to Biden's meetings this week, Education Secretary Arne Duncan will meet with parent and teacher groups, while Health and Human Services Secretary Kathleen Sebelius will meet with mental health and disability advocates.

The White House said other meetings are also scheduled with community organizations, business owners and religious leaders.

___

Follow Julie Pace at http://twitter.com/jpaceDC

Source: http://news.yahoo.com/biden-meet-gun-safety-victims-groups-080451748--politics.html

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Under the Shining Moon (closed)

Rohaan Ja'aisen thrived in the dark just as much as he did in the light of day. Sometimes even more so, as summer often brought with it late nights and festivals in the city or even surrounding villages, where there would be abundant company, food, and enough drink to make people rarely ask questions. Summer nights reminded the wanderer of the home he hadn't seen since his boyhood, of evenings when there was no bedtime, when adults would allow him the tiniest sips of sweet alcohols, when he and the other children would build ci'deia'jun--guardians of sand--at the oceanside. What he wouldn't give to go back to those times...

It was winter now, and its chill brought utter silence, empty streets, and yet a sense of serenity the other seasons couldn't offer. His favorite thing was when he awoke to new snow, untouched and unmarred by people or woodland animals. It was pure. Perfect. Smooth. This particular morning was one of those, but as the day marched on the sun rose higher and melted [i]some[/ i] of the snow. What was left was a sploshy, ugly mess of mud and slush that soaked through Rohaan's boots, through the skin of his toes right down to the bones. It made walking miserable and the thought of sleeping outdoors unbearable, so, deciding to splurge, Rohaan headed for a very small city called Brunia. It was a change of plans, but he'd manage. Originally, Rohaan was going to skirt around the settlement, wait for a few days, and when the timing was right he would seek out his quarry. But this, this would do.

The city was small enough that its sad excuse for a wall was merely a glorified fence; its keeper, bored and tired, only gave Rohaan a passing glance before letting him through. Besides, who would deny a cold, wet traveler sanctuary in the dead of winter? Inside the walls was a quiet part of town; most of the residents were either sleeping or tucked quietly by a fireplace inside their homes. As he moved further in, he began to see more life. Minimal at best, but it was a good sign to see people closing up their shops, dashing between buildings to escape the cold, or walking their horses to a well that had miraculously not frozen over.

A medium sized inn presented itself to Rohaan as an option, and he found it viable enough.?All he needed was a fire to hang his boots by for the night and somewhere to stay for the next couple of days. Before he opened the door Rohaan donned his horn-framed eye shades and adopted his blind persona. Convincingly the traveler stumbled hard over a small step and swung awkwardly in with the heavy wooden door. Rohaan took a moment to 'feel for his surroundings' and made his way to the counter, which doubled as a bar.
"Hello?" He called.
A stern looking woman scrubbing away something stubborn on the inside of a bowl looked up at him, answering unceremoniously with, "what do you want?"
Rohaan turned his head, careful to never look directly at her. "A room please. I can pay, uh...how much for tonight?" He dropped a little pouch of money on the bar that he pulled from one of the pockets on his bandolier that he then began to awkwardly sort through.
"A piece of silver gets you a room and a hot bath."
"Silver, silver. Okay. Uh.." Rohaan hefted a few different coins in his hand; He'd practiced the?art of determining which coin was which based solely on its weight for occasions just like this one. "Here," he said, deciding finally on one and handing it to her.
The woman took it, then came out with a large wooden token that she pushed into his
hands. "I'll put you on the second floor, very end of the hall to your left. Can...can you manage the stairs?"
"I'll be fine, miss."
"That token there will get you a hot bath. Just show it to one of the attendants in the bath house and she'll get one started for you."
"Many thanks, miss." Moving uncertainly to the stairs, Rohaan eased his way up, down the hall, and into the designated room, where he was finally able to drop his facade. The boots were the first things to go, next came his soaked outerwear and gear. Rohaan wasted no time getting into the bath house and cashing in on his luxury promised, the. He changed into fresh clothes, put his boots by the fireplace in his room and went downstairs, 'blind', to get himself a drink. Keeping up his rues for multiple days would be tedious, but his prize was well worth the wait.

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/wm4E4ZbDXCA/viewtopic.php

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Tuesday, January 8, 2013

iBattz beats Mophie to iPhone 5 charging case, ups the ante using interchangable i9300 batteries

iBattz beats Mophie to iPhone 5 charging case, ups the ante using 'interchangable' i9300 batteries

It's usually a no-brainer -- Mophie exits quickly out of the gate with a battery-equipped case soon after a new iDevice gets announced. This year, however, it appears iBattz is poised to hit it out of the park faster with two of its own iPhone 5 cases. Notably, each case comes packed with two swappable i9300 Li-ion battery packs (the same kind for Samsung's rival Galaxy S III, seriously). The cells are rated at 2,200mAh each, which is notably larger in capacity than the iPhone's roughly 1,400mAh batts. The streamlined Mojo Fuel (pictured) will set you back $90 come February, while argonauts can sang the ruggedized Mojo Armor for $100 in March. The cases charge via microUSB, and an external battery charger will also be included with each. The company has also detailed its waterproof AquaSeal Hi5, featuring a detachable 2,500mAh aluminium battery back -- no further details just yet. We'll be sure to report back if catch 'em on the show floor here at CES. Find the full press release after the break.

Continue reading iBattz beats Mophie to iPhone 5 charging case, ups the ante using interchangable i9300 batteries

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/--BfbE1wpKw/

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Yale Study: Costlier Breast Cancer Screenings May Not Help Older ...

A new Yale study finds that newer and costlier screening methods for breast cancer in women age 65 and older don't necessarily bring better results, and suggests that the health care industry rethink screening procedures for women in that age group.

The study, published Monday in the journal JAMA Internal Medicine, finds that Medicare spends more than $1 billion on screening for breast cancer. Of that, $400 million is spent on screening for women age 75 and older, even though the U.S. Preventive Services Task Force says there isn't enough evidence that breast cancer screening provides much benefit for those women.

Dr. Cary Gross, who led the study, said the findings don't suggest that there is no benefit to screening these women but said that $400 million is a lot of money to spend on a procedure "given that we don't really know that it works or not."

Doctors shouldn't stop screening these women, he said, but they should think more about how they do it. For instance, women in the Medicare age group? 65 and older ? can vary greatly in their risk for breast cancer. The benefits of early detection also vary.

"The benefits of screening are directly related to your risks of developing breast cancer and your overall health," he said. "Women who have few other health problems and have a long expectancy would have far more to gain from screening."

Gross is director of the Cancer Outcomes, Public Policy, and Effectiveness Research Center at Yale.

The study also finds significant differences in screening costs, depending on the technology used. Screenings for Medicare patients ranged from $40 to $110 per patient. In areas that adopted more sophisticated ? and more expensive ? technology, such as digital mammography and computer-aided detection, women had higher screening costs but not necessarily a lower rate of cancer that has spread.

"As the field of radiology moves toward digital technology, it is important to note that digital mammography will frequently be the only option available," the researchers write in the study. "Higher costs associated with adoption of newer modalities may not necessarily yield superior outcomes."

For the study, the researchers looked at Medicare money spent on breast cancer screening and treatment of 137,274 female Medicare beneficiaries who had not had breast cancer before 2006. The researchers followed those patients for two years, noting the number of times they were screened, how many developed breast cancer and the costs of their screenings and treatment.

"My hope is that these findings will push the field not only to consider whether [screening is] effective, but also to consider some of the costs of it," he said.

Gross said he thinks the study's findings go along with a general trend of recent years in considering the importance of breast cancer screenings.

"We're just starting to have a tipping point," he said. "There are more skeptics about the benefits of screening and fewer zealots promoting more screening for all patients at all times."

Dr. Colin Begg, biostatistician at Memorial Sloan-Kettering Cancer Center in New York City, said it's a "useful study, with useful data." But Begg, who was not involved in the study, said he is wary that it downplays the importance of mammography.

"They've kind of overreached in implying that we're wasting our money in screening for this age group," he said. "I don't buy it."

But Dr. Otis Brawley, chief medical officer of the American Cancer Society, said the study correlates with "all my prejudices about American medicine." Medicare is too quick to adopt the latest technologies without enough study on how to use them. Digital mammography is good technology, he said ? so good that it often results in detecting tumors so small that they pose little risk. Once detected, however, they often get treated.

"Our wisdom on how to use these new technologies has not kept up with our abilities to develop these technologies," Brawley said.

Dr. Laura Esserman, director of the breast care center at the University of California in San Francisco, said the study's findings are consistent with her own research. Screenings are important, she said, but the health care industry has put too much faith in them.

"They make it something that it's not," she said. "You can't expect something from it that it can't deliver."

The more doctors learn about breast cancer, she said, the more it's apparent that the benefits of early detection vary significantly.

"Breast cancer's not one disease ? it's several diseases," she said. "And our understanding of screening has not kept up with our changing notions of what breast cancer is."

Source: http://www.courant.com/health/connecticut/hc-cancer-screen-study-0108-20130107,0,3599731.story

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Galaxy's gamma-ray flares erupted far from its black hole

Jan. 7, 2013 ? In 2011, a months-long blast of energy launched by an enormous black hole almost 11 billion years ago swept past Earth. Using a combination of data from NASA's Fermi Gamma-ray Space Telescope and the National Science Foundation's Very Long Baseline Array (VLBA), the world's largest radio telescope, astronomers have zeroed in on the source of this ancient outburst.

Theorists expect gamma-ray outbursts occur only in close proximity to a galaxy's central black hole, the powerhouse ultimately responsible for the activity. A few rare observations suggested this is not the case.

The 2011 flares from a galaxy known as 4C +71.07 now give astronomers the clearest and most distant evidence that the theory still needs some work. The gamma-ray emission originated about 70 light-years away from the galaxy's central black hole.

The 4C +71.07 galaxy was discovered as a source of strong radio emission in the 1960s. NASA's Compton Gamma-Ray Observatory, which operated in the 1990s, detected high-energy flares, but the galaxy was quiet during Fermi's first two and a half years in orbit.

In early November 2011, at the height of the outburst, the galaxy was more than 10,000 times brighter than the combined luminosity of all of the stars in our Milky Way galaxy.

"This renewed activity came after a long slumber, and that's important because it allows us to explicitly link the gamma-ray flares to the rising emission observed by radio telescopes," said David Thompson, a Fermi deputy project scientist at NASA's Goddard Space Flight Center in Greenbelt, Md.

Located in the constellation Ursa Major, 4C +71.07 is so far away that its light takes 10.6 billion years to reach Earth. Astronomers are seeing this galaxy as it existed when the universe was less than one-fourth of its present age.

At the galaxy's core lies a supersized black hole weighing 2.6 billion times the sun's mass. Some of the matter falling toward the black hole becomes accelerated outward at almost the speed of light, creating dual particle jets blasting in opposite directions. One jet happens to point almost directly toward Earth. This characteristic makes 4C +71.07 a blazar, a classification that includes some of the brightest gamma-ray sources in the sky.

Boston University astronomers Alan Marscher and Svetlana Jorstad routinely monitor 4C +71.07 along with dozens of other blazars using several facilities, including the VLBA.

The instrument's 10 radio telescopes span North America, from Hawaii to St. Croix in the U.S. Virgin Islands, and possess the resolving power of a single radio dish more than 5,300 miles across when their signals are combined. As a result, The VLBA resolves detail about a million times smaller than Fermi's Large Area Telescope (LAT) and 1,000 times smaller than NASA's Hubble Space Telescope.

In autumn 2011, the VLBA images revealed a bright knot that appeared to move outward at a speed 20 times faster than light.

"Although this apparent speed was an illusion caused by actual motion almost directly toward us at 99.87 percent the speed of light, this knot was the key to determining the location where the gamma-rays were produced in the black hole's jet," said Marscher, who presented the findings Monday at the American Astronomical Society meeting in Long Beach, Calif.

The knot passed through a bright stationary feature of the jet, which the astronomers refer to as its radio "core," on April 9, 2011. This occurred within days of Fermi's detection of renewed gamma-ray flaring in the blazar. Marscher and Jorstad noted that the blazar brightened at visible wavelengths in step with the higher-energy emission.

During the most intense period of flaring, from October 2011 to January 2012, the scientists found the polarization direction of the blazar's visible light rotated in the same manner as radio emissions from the knot. They concluded the knot was responsible for the visible and the gamma-ray light, which varied in sync.

This association allowed the researchers to pinpoint the location of the gamma-ray outburst to about 70 light-years from the black hole.

The astronomers think that the gamma rays were produced when electrons moving near the speed of light within the jet collided with visible and infrared light originating outside of the jet. Such a collision can kick the light up to much higher energies, a process known as inverse-Compton scattering.

The source of the lower-energy light is unclear at the moment. The researchers speculate the source may be an outer, slow-moving sheath that surrounds the jet. Nicholas MacDonald, a graduate student at Boston University, is investigating how the gamma-ray brightness should change in this scenario to compare with observations.

"The VLBA is the only instrument that can bring us images from so near the edge of a young supermassive black hole, and Fermi's LAT is the only instrument that can see the highest-energy light from the galaxy's jet," said Jorstad.

NASA's Fermi Gamma-ray Space Telescope is an astrophysics and particle physics partnership. Fermi is managed by NASA's Goddard Space Flight Center. It was developed in collaboration with the U.S. Department of Energy, with contributions from academic institutions and partners in France, Germany, Italy, Japan, Sweden and the United States.

The VLBA is operated by the National Radio Astronomy Observatory, a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.

For images related to this finding and to learn more about Fermi, visit: http://go.nasa.gov/TGwz3N

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The above story is reprinted from materials provided by NASA.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/VWYA2QZIjsI/130107175006.htm

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Thursday, December 27, 2012

Genetic sequencing breakthrough to aid treatment for congenital hyperinsulinism

Dec. 27, 2012 ? Congenital hyperinsulinism is a genetic condition where a baby's pancreas secretes too much insulin. It affects approximately one in 50,000 live births and in severe cases requires the surgical removal of all or part of the pancreas.

Researchers at the University of Exeter Medical School are the first in the world to utilise new genetic sequencing technology to sequence the entirety of a gene in order to identify mutations that cause hyperinsulinism. Previously, existing technology limited such sequencing to only part of the coding regions of the gene which meant that some mutations were missed.

Using new Illumina genetic sequencing technology, the research team led by Professor Sian Ellard has discovered novel mutations that cause hyperinsulinism. Their findings are published December 27 2012, on-line by The American Journal of Human Genetics.

The outcome will be that some infants born with hyperinsulinism will require fewer investigations, because the new technology means that for many only one genetic test will be required to determine the extent of the condition in each child. It also means that clinicians will have more information at their fingertips to inform them about how much of the pancreas needs to be removed.

Approximately 50 per cent of patients with congenital hyperinsulinism require surgery, and of those half require the entire pancreas to be removed. Removal of the entire pancreas increases the risk of diabetes later in life, but if left undiagnosed and untreated hyperinsulinism can result in irreparable brain damage. Symptoms range from shakiness and tiredness to seizure and coma.

Dr. Sarah Flanagan, Research Fellow in Molecular Genetics at the University of Exeter Medical School said: "The potential provided by this new technology is important and exciting, because it allows us to investigate genetic coding in its entirety. This means that investigators can identify mutations that sit at the heart of any number of conditions where before they might have been missed. This in turn results in better information for clinicians upon which they can base effective treatments and interventions for their patients."

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The above story is reprinted from materials provided by University of Exeter, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Sarah?E. Flanagan, Weijia Xie, Richard Caswell, Annet Damhuis, Christine Vianey-Saban, Teoman Akcay, Feyza Darendeliler, Firdevs Bas, Ayla Guven, Zeynep Siklar, Gonul Ocal, Merih Berberoglu, Nuala Murphy, Maureen O?Sullivan, Andrew Green, Peter?E. Clayton, Indraneel Banerjee, Peter?T. Clayton, Khalid Hussain, Michael?N. Weedon, Sian Ellard. Next-Generation Sequencing Reveals Deep Intronic Cryptic ABCC8 and HADH Splicing Founder Mutations Causing Hyperinsulinism by Pseudoexon Activation. The American Journal of Human Genetics, 2012; DOI: 10.1016/j.ajhg.2012.11.017

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/Hvyf7POeyVQ/121227130325.htm

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